I would vacuum every time you change the water and I see no reason to stop at 22% unless you are buying RO water or have a water shortage. I do 50% water changes every time, 2 to 4 times a month. My frequency of water changes is based on bio-load. I understock most of my tanks. The nice thing about a 50% changes is that you are cutting waste levels in half assuming that your water source is 0.
how big is the tank and what are the current filters?
how big is the tank and what are the current filters?