hello, i have a 5.5g nano. i dont have a protein skimmer with mine. just 2 filters with nothing in them for current. all my filtration is with the live rock. u need a lb of live rock for every gallon in your tank if u do it that way. also you need a lb of live sand for every gallon as well. at least thats what i didn. with tanks these sizes a protein skimmer really isnt necessary as long as you have enough live rock. you'll need a good cleaner crew (snails crabs etc). in mine i have 2 turbo snail and 2 hermit crabs. also a coral banded shrimp (mind you those guys can be a little aggresive and territorial). for fish you'll prob only be able to get one. a smaller clown fish or maybe a fire fish. water changes are very important because salt water fish don't tolerate poor water conditions. you'll want to get a test kit. your ammonia, nitrite should always be 0. your nitrate should be kept below 20. i keep my nano at about 81-82 degrees. lots of info but if you decide to set one up they certainly are amazing! 